Ceftriaxone Sodium for Injection

Cefriaxone Sodium for Injection BP is indicated for the treatment of the following infections when caused by susceptible strains of the designated micro-organisms:

  • Lower Respiratory tract infections caused by E. coli, H. influenzae, K. pneumoniae and species, Staph. aureus, Strep. pneumoniae and species (excluding enterococci).
  • Urinary tract infections (complicated and uncomplicated) caused by E. coli, Klebsiella species,
  • P. mirabilis and P. vulgaris.
  • Bacterial Septicemia caused by E. coli, H. influenzae, K. pneumoniae, Staph. aureus and Strep. pneumoniae, (excluding enterococci).
  • Skin and Skin Structure Infections caused by K. pneumoniae and species, P. mirabilis, Staph. aureus, Staph. epidermidis and Streptococcus species (excluding enterococci).
  • Bone and Joint Infections caused by Staph. aureus, Strep. pneumoniae and Streptococcus species (excluding enterococci).
  • Intra-Abdominal Infections caused by E.coli and K. pneumoniae.
  • Meningitis caused by H. influenzae, N. meningitidis, and Strep. pneumoniae. Ceftriaxone Sodium for Injection BP (ceftriaxone sodium) should not be used for the treatment of meningitis caused by L. monocytogenes.
  • Uncomplicated Gonorrhea (cervical/urethral, pharyngeal and rectal) caused by N. gonorrhoeae (penicillinase and nonpenicillinase producing strains).

Susceptibility Testing: Specimens for bacteriologic culture should be obtained prior to therapy in order to identify the causative organisms and to determine their susceptibilities to ceftriaxone. Therapy may be instituted before results of susceptibility testing are known. However, modification of the treatment may be required once these results become available.

Prophylaxis:  The preoperative administration of a single 1 g dose of Ceftriaxone Sodium for Injection BP may reduce the incidence of postoperative infections in patients undergoing vaginal or abdominal hysterectomy, coronary artery bypass surgery, or in patients at risk of infection undergoing biliary tract surgery. If signs of post surgical infection should appear, specimens for culture should be obtained for identification of the causative organism(s) so that the appropriate therapy may be instituted.

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